Mitochondrial Recombination Reveals Mito–Mito Epistasis in Yeast
نویسندگان
چکیده
منابع مشابه
A Genome-Wide Map of Mitochondrial DNA Recombination in Yeast
In eukaryotic cells, the production of cellular energy requires close interplay between nuclear and mitochondrial genomes. The mitochondrial genome is essential in that it encodes several genes involved in oxidative phosphorylation. Each cell contains several mitochondrial genome copies and mitochondrial DNA recombination is a widespread process occurring in plants, fungi, protists, and inverte...
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In S. cerevisiae, mitochondrial DNA (mtDNA) molecules, in spite of their high copy number, segregate as if there were a small number of heritable units. The rapid segregation of mitochondrial genomes can be analyzed using mtDNA deletion variants. These small, amplified genomes segregate preferentially from mixed zygotes relative to wild-type mtDNA. This segregation advantage is abolished by mut...
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Mitochondria contain an independently maintained genome that encodes several proteins required for cellular respiration. Deletions in the mitochondrial genome have been identified that cause several maternally inherited diseases and are associated with certain cancers and neurological disorders. The majority of these deletions in human cells are flanked by short, repetitive sequences, suggestin...
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1 Rb7 . . . . . 2 Rn8 . . . . . 3 Rc6 . . . . . 4 Ra1 . . . . . 5 Rd5 . . . . . 6 Rd4 . . . . . 7 Rr2 . . . . . 8 Rr3 . . . . . AF205088 AF205087 AF205089 AF205094 AF205090 AF205091 AF205093 AF205092 R. plancyi R. nigromaculata R. catesbeiana R. amurensis R. dybowskii R. dybowskii R. rugosa R. rugosa Previous attempts to demonstrate, or refute, the occurrence of recombination in mitochondria ha...
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ژورنال
عنوان ژورنال: Genetics
سال: 2018
ISSN: 1943-2631
DOI: 10.1534/genetics.117.300660